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Articles in Press
5/14/2026 6:25:45 AM | Browse: 7 | Download: 0
| Category |
Clinical Neurology |
| Manuscript Type |
Opinion Review |
| Article Title |
Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zi-Wei Hou, Pan Zhang and Chen Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanxi Province Chinese Medicine Science and Technology Special Research Project |
No. 2024ZYY2A023 |
| Integration of Medicine, Engineering, and Basic Medical Sciences Special Project of Shanxi Provincial Health Commission |
No. 2025YGYL026 |
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| Corresponding Author |
Chen Chen, Department of Neurology, Affiliated Cardiovascular Hospital of Shanxi Medical University, No. 18 Yifen Street, Taiyuan 030024, Shanxi Province, China. chen.chen@sxmu.edu.cn |
| Key Words |
Gut microbiota; Aging; Gut-liver axis; Gut-brain axis; Neuroinflammation; Multi-organ axis; Traditional Chinese medicine |
| Core Tip |
Recent studies have observed functional remodeling of gut microbiota during aging, particularly enhanced lipid metabolism pathways. This article discusses the gut-liver axis and gut-brain axis as potential bridges linking microbial alterations to host aging, with neuroinflammation potentially acting as an integrative hub. Targeting the “microbiota-multi-organ axis-neuroinflammation” network may provide potential directions for future research on healthy aging. |
| Citation |
Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; In press |
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Received |
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2026-01-30 01:00 |
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Peer-Review Started |
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2026-01-30 06:57 |
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First Decision by Editorial Office Director |
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2026-02-26 08:17 |
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Return for Revision |
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2026-02-26 08:17 |
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Revised |
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2026-04-19 02:53 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-14 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-14 06:25 |
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Articles in Press |
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2026-05-14 06:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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