Publication Name	World Journal of Clinical Oncology
Manuscript ID	119535
Country	Germany

Category	Orthopedics
Manuscript Type	Retrospective Cohort Study
Article Title	Risk factors for postoperative pathological fractures in lower extremity soft tissue sarcoma patients undergoing limb-sparing surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Axel Horsch, Christopher Baus, Julian Deisenhofer, Andre Lunz, Andreas Geisbüsch and Burkhard Lehner
Funding Agency and Grant Number	Funding Agency Grant Number Heidelberg University
Corresponding Author	Axel Horsch, Associate Professor, Department of Orthopedics, University Hospital Heidelberg, Schlierbacher Landstraße 200a, Heidelberg 69118, Baden-Württemberg, Germany. axel.horsch@med.uni-heidelberg.de
Key Words	Soft tissue sarcoma; Limb-sparing surgery; Postoperative pathological fracture; Radiotherapy; Bone resection
Core Tip	Postoperative pathologic fractures are an underrecognized late complication following limb-sparing surgery for lower extremity soft tissue sarcoma (STS). In this retrospective cohort of 266 patients with long-term follow-up, fractures occurred predominantly in the femur and often several years after treatment. Partial bone resection and osteoporosis were independently associated with increased fracture risk, whereas radiotherapy showed an elevated but not statistically significant association. These findings underscore the importance of long-term surveillance and careful risk stratification in patients undergoing limb-sparing management for STS.
Citation	Horsch A, Baus C, Deisenhofer J, Lunz A, Geisbüsch A, Lehner B. Risk factors for postoperative pathological fractures in lower extremity soft tissue sarcoma patients undergoing limb-sparing surgery. World J Clin Oncol 2026; In press

Received	2026-01-30 01:40
Peer-Review Started	2026-01-30 01:42
First Decision by Editorial Office Director	2026-02-10 10:28
Return for Revision	2026-02-10 10:28
Revised	2026-04-07 06:33
Publication Fee Transferred
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 08:39
Articles in Press	2026-05-08 08:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com