Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119538
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Min Li, Xiao-Peng Wang, Yu-Xuan Li, Yi-Dong Wang, Yi-Jie Sun, Guo-Dong Li and Jia-Qi Wu
Funding Agency and Grant Number	Funding Agency Grant Number Hangzhou Biomedical and Health Industry Development Support Technology Special Project No. 2023WJC080 Hangzhou Medical and Health Science and Technology Project No. A20251519
Corresponding Author	Jia-Qi Wu, MD, Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Hangzhou 310000, Zhejiang Province, China. wujiaqi_12@126.com
Key Words	Linaclotide; Bowel preparation; High-risk patients; Boston bowel preparation scale; Adequate preparation rate
Core Tip	This randomized controlled trial evaluated the efficacy of 3 L polyethylene glycol combined with linaclotide in patients at high risk of inadequate bowel preparation. Linaclotide significantly improved bowel cleansing and the adequacy of bowel preparation. No differences were observed between the groups in adenoma detection rate, polyp detection rate, polyp characteristics, or adverse events. This novel evidence supports the use of 3 L polyethylene glycol with linaclotide for bowel cleansing in high-risk populations.
Citation	Li WM, Wang XP, Li YX, Wang YD, Sun YJ, Li GD, Wu JQ. Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial. World J Gastrointest Surg 2026; In press

Received	2026-02-02 03:25
Peer-Review Started	2026-02-02 03:26
First Decision by Editorial Office Director	2026-02-27 06:53
Return for Revision	2026-02-27 06:53
Revised	2026-03-11 13:35
Publication Fee Transferred	2026-03-17 15:21
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 08:28
Articles in Press	2026-04-01 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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