Publication Name	World Journal of Gastroenterology
Manuscript ID	119545
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions
Manuscript Source	Invited Manuscript
All Author List	Hai-Bo Wu, Ting Chen and Yi Tian
Funding Agency and Grant Number
Corresponding Author	Yi Tian, MD, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, No. 522 Xiwaita Stone Road, Tongchuan District, Dazhou 635000, Sichuan Province, China. doc.yitian@hotmail.com
Key Words	Gut microbiome; Aging; Trimetazidine; Microbial balance; Metabolism; Senescence; Predictive model
Core Tip	In this letter, we discuss a study by Wang et al on the age-related gut microbiome profile and reversal of microbial imbalance using trimetazidine therapy. This study provided compelling evidence that the gut microbiota undergoes significant age-dependent changes, particularly an enrichment of fatty acid oxidation-related microbes in older populations. The authors successfully demonstrated that trimetazidine restored the gut microbial balance and reduced senescence markers in ageing rats, indicating that it exerts potential anti-ageing effects by modulating the microbiota and metabolism.
Citation	Wu HB, Chen T, Tian Y. Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions. World J Gastroenterol 2026; In press

Received	2026-01-30 00:48
Peer-Review Started	2026-01-30 00:55
First Decision by Editorial Office Director	2026-02-10 10:52
Return for Revision	2026-02-10 10:52
Revised	2026-02-13 01:37
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 10:26
Articles in Press	2026-03-10 10:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com