Publication Name	World Journal of Stem Cells
Manuscript ID	119550
Country	China

Category	Cell Biology
Manuscript Type	Retrospective Study
Article Title	Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Lin-Lin Luo, Si-Cong Jiang, Shuo Li, Guang-Yi Zhang, Jian-Jun Tang and You-Dan Guo
Funding Agency and Grant Number
Corresponding Author	You-Dan Guo, MD, Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, No. 92 Aiguo Road, Nanchang 330006, Jiangxi Province, China. 13970945069@163.com
Key Words	Non-small cell lung cancer; Cancer stem cells; CD133; Aldehyde dehydrogenase 1A1; SRY-box transcription factor 2; Prognosis
Core Tip	Cancer stem cells (CSCs) are key drivers of tumor recurrence, metastasis, and therapeutic resistance in non-small cell lung cancer. This retrospective study systematically evaluated the prognostic significance of the CSC-related markers CD133, aldehyde dehydrogenase 1A1, and SRY-box transcription factor 2 using immunohistochemistry in surgically resected non-small cell lung cancer tissues. We further developed a composite CSC score integrating multiple stemness markers, which significantly improved the prognostic stratification beyond conventional clinicopathological factors. Its potential clinical value lies in complementary postoperative risk enrichment, closer surveillance planning, and future integration with molecular subtyping, rather than the replacement of existing decision frameworks.
Citation	Luo LL, Jiang SC, Li S, Zhang GY, Tang JJ, Guo YD. Cancer stem cell-associated markers and their prognostic value in non-small cell lung cancer. World J Stem Cells 2026; In press

Received	2026-03-25 10:19
Peer-Review Started	2026-03-25 10:19
First Decision by Editorial Office Director	2026-04-10 07:52
Return for Revision	2026-04-10 07:52
Revised	2026-04-24 11:31
Publication Fee Transferred	2026-04-28 02:39
Second Decision by Editor	2026-05-20 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-27 08:03
Articles in Press	2026-05-27 08:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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