Publication Name	World Journal of Hepatology
Manuscript ID	119561
Country	China

Category	Biology
Manuscript Type	Basic Study
Article Title	LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Yang, Shi-Li Wu, Zhi-Hao Huang, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Yi Gao, Wei-Jie Zhou and Yuan Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program 2022YFA1106700 National Natural Science Foundation of China No. 82270645, No. 82570748 National Natural Science Foundation of China No. 82200633, No. 92068206
Corresponding Author	Yuan Lin, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. xiaoyuanlinz@163.com
Key Words	Leukocyte-derived chemotaxin-2; Tie1; Src kinase; Endothelial cells; Oxidative stress; Ischemia-reperfusion injury; Liver injury
Core Tip	This study elucidates a novel signaling mechanism in which leukocyte-derived chemotaxin-2 exacerbates hepatic ischemia-reperfusion injury by binding to Tie1 and activating Src kinase, thereby amplifying oxidative stress and endothelial cell damage. Targeting the leukocyte-derived chemotaxin-2/Tie1/Src axis represents a promising therapeutic strategy for mitigating liver ischemia-reperfusion injury, offering potential translational applications in liver surgery and transplantation.
Citation	Yang Y, Wu SL, Huang ZH, Dong MQ, Liu ZM, Xu M, Gao Y, Zhou WJ, Lin Y. LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury. World J Hepatol 2026; In press

Received	2026-02-02 05:34
Peer-Review Started	2026-02-02 05:35
First Decision by Editorial Office Director	2026-02-10 10:29
Return for Revision	2026-02-10 10:29
Revised	2026-02-24 06:50
Publication Fee Transferred	2026-02-25 05:20
Second Decision by Editor	2026-04-17 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-17 08:07
Articles in Press	2026-04-17 08:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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