Publication Name	World Journal of Gastroenterology
Manuscript ID	119567
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic value of systemic immune-inflammation index in patients with gastric cancer treated with immune checkpoint inhibitors
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Guo and Meng Gao
Funding Agency and Grant Number
Corresponding Author	Rui Guo, Department of Laboratory Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 462000, Henan Province, China. guorui2460@163.com
Key Words	Systemic immune-inflammation index; Gastric cancer; Immune checkpoint inhibitors; Prognosis; Biomarkers; Retrospective studies
Core Tip	The systemic immune-inflammation index (SII), calculated from routine blood counts, integrates neutrophils, lymphocytes, and platelets to reflect the host immune-inflammatory balance. This retrospective study of 238 advanced gastric cancer patients treated with immune checkpoint inhibitors demonstrates that a high baseline SII (≥ 593.995) independently predicts poor progression-free survival and lower disease control rates. Combining SII with clinical parameters significantly improves predictive accuracy for early progressive disease, suggesting SII as a practical and accessible biomarker for risk stratification in immune checkpoint inhibitors-treated gastric cancer.
Citation	Guo R, Gao M. Prognostic value of systemic immune-inflammation index in patients with gastric cancer treated with immune checkpoint inhibitors. World J Gastroenterol 2026; In press

Received	2026-03-03 10:28
Peer-Review Started	2026-03-03 10:28
First Decision by Editorial Office Director	2026-03-13 09:11
Return for Revision	2026-03-13 09:11
Revised	2026-03-25 03:53
Publication Fee Transferred	2026-03-31 01:26
Second Decision by Editor	2026-05-11 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 08:06
Articles in Press	2026-05-11 08:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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