Publication Name	World Journal of Stem Cells
Manuscript ID	119568
Country	South Korea

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Epiregulin-EGFR-ERK1/2 signaling as a therapeutic axis for rescuing mesenchymal stem cell dysfunction in inflammatory periodontal niches
Manuscript Source	Invited Manuscript
All Author List	Kruthika Prakash, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran and Byeong-Cheol Ahn
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program Through the National Research Foundation of Korea NRF-2022R1I1A1A01068652
Corresponding Author	Byeong-Cheol Ahn, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, 680, Gukchaebosang ro, Jung gu, Daegu 41944, South Korea. abc2000@knu.ac.kr
Key Words	Epiregulin; Mesenchymal stem cells; Periodontitis; Inflammatory niche; Epidermal growth factor receptor-extracellular signal-regulated kinase signaling
Core Tip	Epiregulin restores inflammation-impaired bone marrow mesenchymal stem cell function via epidermal growth factor receptor-extracellular signal-regulated kinase signaling, highlighting its potential as a promising therapeutic target for periodontal regeneration under inflammatory conditions. By activating this pathway, epiregulin rescues key stem cell functions, including proliferation, migration, and osteogenic differentiation, that are suppressed by inflammatory stimuli such as tumor necrosis factor-alpha, offering a mechanistically driven and inflammation-resilient strategy for periodontal tissue regeneration and clinical translation.
Citation	Prakash K, ArulJothi KN, Rajendran RL, Gangadaran P, Ahn BC. Letter to the Editor: Epiregulin-EGFR-ERK1/2 signaling as a therapeutic axis for rescuing mesenchymal stem cell dysfunction in inflammatory periodontal niches. World J Stem Cells 2026; In press

Received	2026-02-02 01:12
Peer-Review Started	2026-02-02 01:12
First Decision by Editorial Office Director	2026-03-20 10:14
Return for Revision	2026-03-20 10:14
Revised	2026-03-29 09:44
Publication Fee Transferred
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 11:02
Articles in Press	2026-05-08 11:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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