Publication Name	World Journal of Nephrology
Manuscript ID	119581
Country	Egypt

Category	Medicine, General & Internal
Manuscript Type	Prospective Study
Article Title	Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Amira A A Othman, Magy Magdy Mohamed, Mona Mahmoud Eladl and Fatma M Attia Elsayed
Funding Agency and Grant Number
Corresponding Author	Amira A A Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Faculty of Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Neutrophil gelatinase-associated lipocalin; Renal Doppler; Acute kidney injury; Cirrhosis; Biomarkers; XGBoost; Resource-efficient
Core Tip	Acute kidney injury (AKI) in cirrhosis is frequently underdiagnosed in resource-limited settings due to the unreliability of serum creatinine. This prospective Egyptian study, conducted in the hepatitis C virus-endemic population, demonstrates that integrating serum neutrophil gelatinase-associated lipocalin, cystatin C, and renal resistive index enables earlier AKI detection, accurate subtyping (pre-renal, hepatorenal syndrome, acute tubular necrosis), and improved short-term prognostication. We provide the first region-specific evidence that a simple neutrophil gelatinase-associated lipocalin-renal resistive index-based algorithm, supported by point-of-care ultrasound, can guide clinical triage and reduce unnecessary intensive care unit utilization in real-world Egyptian practice. These findings offer a practical, scalable diagnostic framework for cirrhosis-associated AKI in low-income and middle-income countries.
Citation	Othman AAA, Mohamed MM, Eladl MM, Elsayed FMA. Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis. World J Nephrol 2026; In press

Received	2026-02-02 00:53
Peer-Review Started	2026-02-02 00:54
First Decision by Editorial Office Director	2026-02-06 10:21
Return for Revision	2026-02-06 10:21
Revised	2026-02-07 19:30
Publication Fee Transferred
Second Decision by Editor	2026-03-24 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-24 09:47
Articles in Press	2026-03-24 09:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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