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Publication Name World Journal of Clinical Pediatrics
Manuscript ID 119602
Country Viet Nam
Category Pediatrics
Manuscript Type Case Report
Article Title Clinical recovery of severe infantile Angiostrongylus cantonensis meningoencephalomyelitis treated with pulse methylprednisolone: A case report and review of literature
Manuscript Source Invited Manuscript
All Author List Bao Trung Nguyen, Luan Thanh Vo, Uyen Hai Pham, Hung Nam Tran, Oanh Hoang-Tran Dang, Dat Tat Nguyen, Tuong Trong-Hanh Tran, Lien Thi To, Viet Chau Do and Thanh Tat Nguyen
Funding Agency and Grant Number
Corresponding Author Thanh Tat Nguyen, MD, PhD, Senior Researcher, Department of Infectious Diseases, Children’s Hospital 2, Ly Tu Trong, Ho Chi Minh City 700000, Viet Nam. thanhhonor@gmail.com
Key Words Angiostrongylus cantonensis; Eosinophilic meningoencephalomyelitis; Infant; Albendazole; Pulse methylprednisolone; Case report
Core Tip Angiostrongylus cantonensis meningoencephalomyelitis in infants is rare and often fatal. We report a case of a 10-month-old infant with deep coma, flaccid quadriplegia, and neurogenic shock who achieved near-complete neurological recovery. Early administration of pulse methylprednisolone (30 mg/kg/day for 5 days) combined with albendazole was associated with a favorable outcome. This case supports the early use of high-dose pulse corticosteroid therapy to attenuate inflammatory neurological injury and improve the prognosis in critically ill infants with severe eosinophilic meningoencephalomyelitis.
Citation Nguyen BT, Vo LT, Pham UH, Tran HN, Dang OHT, Nguyen DT, Tran TTH, To LT, Do VC, Nguyen TT. Clinical recovery of severe infantile Angiostrongylus cantonensis meningoencephalomyelitis treated with pulse methylprednisolone: A case report and review of literature. World J Clin Pediatr 2026; In press
Received
2026-02-02 00:51
Peer-Review Started
2026-02-02 00:52
First Decision by Editorial Office Director
2026-02-28 07:00
Return for Revision
2026-02-28 07:00
Revised
2026-03-06 15:04
Publication Fee Transferred
Second Decision by Editor
2026-03-23 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-23 08:03
Articles in Press
2026-03-23 08:03
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ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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