Publication Name	World Journal of Gastroenterology
Manuscript ID	119613
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Pattern and risk factors for postoperative recurrence in borderline resectable pancreatic cancer after upfront surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Han-Xuan Wang, Qing Zhao, Jin-Can Huang, Qiang He, Shao-Cheng Lyu and Ren Lang
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Research Incubation Project, Beijing Chao-Yang Hospital, Capital Medical University No. CYFH202302
Corresponding Author	Ren Lang, Professor, Division of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing 100020, China. dr_langren123@126.com
Key Words	Borderline resectable pancreatic cancer; Upfront surgery; Tumor recurrence; Pattern; Risk factor
Core Tip	This study characterized the recurrence patterns in borderline resectable pancreatic cancer patients undergoing upfront surgery. It identified that early recurrence, predominantly liver metastasis within the first year, is a major challenge. Preoperative carcinoembryonic antigen level, tumor diameter, poor differentiation, and lymph node metastasis were identified as independent risk factors, whereas the extent of vascular invasion showed limited association. These findings improved the understanding of postoperative tumor recurrence in borderline resectable pancreatic cancer patients and would help clinicians make optimal treatment decision so as to improve the prognosis of these patients.
Citation	Wang HX, Zhao Q, Huang JC, He Q, Lyu SC, Lang R. Pattern and risk factors for postoperative recurrence in borderline resectable pancreatic cancer after upfront surgery. World J Gastroenterol 2026; In press

Received	2026-02-02 02:50
Peer-Review Started	2026-02-02 02:51
First Decision by Editorial Office Director	2026-02-04 10:13
Return for Revision	2026-02-04 10:13
Revised	2026-02-15 07:41
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 08:35
Articles in Press	2026-03-10 08:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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