Publication Name	World Journal of Gastroenterology
Manuscript ID	119619
DOI	10.3748/wjg.119619
Country	Poland

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study
Manuscript Source	Unsolicited Manuscript
All Author List	Kamila A Kwiatek-Średzińska, Kinga Trochimczyk, Jacek Jamiołkowski and Dariusz M Lebensztejn
Funding Agency and Grant Number	Funding Agency Grant Number Medical University of Bialystok, Poland No. SUB/1/DN/22/002/1143 and No. B.SUB.26.422
Corresponding Author	Kamila A Kwiatek-Średzińska, MD, Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, Bialystok 15-274, Poland. kamila.kwiatek-sredzinska@umb.edu.pl
Key Words	Trypsinogen-1; Trypsinogen-2; Trypsinogen activation peptide; Urinary biomarkers; Acute pancreatitis; Pediatric pancreatitis; Children
Core Tip	This is the first observational study in children evaluating the usefulness of urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis. Urinary trypsinogen-2 may serve as a noninvasive biomarker of acute pancreatitis, whereas urinary trypsinogen activation peptide may reflect disease severity in children, although with certain time-dependent limitations. Assessment of urinary parameters offers a simple, noninvasive, and painless approach with potential clinical utility.
Citation	Kwiatek-Średzińska KA, Trochimczyk K, Jamiołkowski J, Lebensztejn DM. Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.119619

Received	2026-02-12 02:46
Peer-Review Started	2026-02-12 02:46
First Decision by Editorial Office Director	2026-04-03 07:44
Return for Revision	2026-04-03 07:44
Revised	2026-04-20 17:58
Publication Fee Transferred	2026-04-27 10:14
Second Decision by Editor	2026-06-03 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-03 07:24
Articles in Press	2026-06-03 07:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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