Publication Name	World Journal of Gastroenterology
Manuscript ID	119629
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study
Manuscript Source	Unsolicited Manuscript
All Author List	Kai-Ling Xie, Gang Long, Lian-Wen Yuan and Dan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Fundamental Research Funds for the Central Universities of Central South University 2024ZZTS0959 National Natural Science Foundation of China 82270590 Hunan Provincial Natural Science Foundation 2025JJ50584 Research Project on Degree and Graduate Education Reform at Central South University
Corresponding Author	Dan Zhang, Professor, Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. dunbaby@126.com
Key Words	Crohn’s disease; Prealbumin; Abdominal surgery; Postoperative endoscopic recurrence; Machine learning; Predictive and personal medicine
Core Tip	Serum prealbumin (PA), reflecting inflammatory and nutritional status, may serve as a pragmatic biomarker for risk stratification in Crohn’s disease. Higher PA levels were associated with lower risks of abdominal surgery and postoperative endoscopic recurrence (highest vs lowest quartile: Hazard ratio = 0.45 and 0.20, respectively). Incorporating PA into machine learning models further improved prognostic performance (C-index = 0.784 for surgery and 0.764 for recurrence). Moreover, serum PA showed approximately 70% concordance with machine learning-derived risk tiers and helped identify patients more likely to benefit from biologic therapy, thereby supporting earlier risk prediction and more individualized treatment decisions.
Citation	Xie KL, Long G, Yuan LW, Zhang D. Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study. World J Gastroenterol 2026; In press

Received	2026-02-02 02:12
Peer-Review Started	2026-02-02 02:15
First Decision by Editorial Office Director	2026-03-12 08:56
Return for Revision	2026-03-12 08:56
Revised	2026-03-31 16:53
Publication Fee Transferred
Second Decision by Editor	2026-04-23 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-23 06:34
Articles in Press	2026-04-23 06:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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