Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119632
DOI	10.4251/wjgo.119632
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Triplet vs doublet adjuvant chemotherapy for gastric cancer: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Chang-Tao Yu, Jin-Kai Wang, Bai-Xue Qin and Guang-Yuan Wang
Funding Agency and Grant Number
Corresponding Author	Guang-Yuan Wang, Department of Gastroenterology, The Second People’s Hospital of Liaocheng, No. 306, Jiankang Street, Xianfeng Subdistrict Office, Linqing City, Liaocheng 252600, Shandong Province, China. guangyuanwang2025@163.com
Key Words	Gastric cancer; Adjuvant chemotherapy; Postoperative chemotherapy; Triplet chemotherapy; Doublet chemotherapy; Meta-analysis
Core Tip	This comprehensive meta-analysis of 12 randomized controlled trials encompassing 11126 patients demonstrates that taxane-platinum-fluoropyrimidine triplet chemotherapy significantly improves objective response rate (1.73-fold increase) and disease control rate (1.22-fold increase) compared to platinum-fluoropyrimidine doublet regimens in neoadjuvant treatment of gastric cancer. Despite superior tumor response, no significant survival benefits were observed. Importantly, safety profiles were comparable between regimens. These findings support individualized treatment selection, with triplet regimens preferred for maximal tumor downstaging when surgical resectability is borderline.
Citation	Yu CT, Wang JK, Qin BX, Wang GY. Triplet vs doublet adjuvant chemotherapy for gastric cancer: A systematic review and meta-analysis. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.119632
PDF	119632-in-press.pdf

Received	2026-03-25 10:20
Peer-Review Started	2026-03-25 10:20
First Decision by Editorial Office Director	2026-04-15 07:45
Return for Revision	2026-04-15 07:45
Revised	2026-06-02 10:24
Publication Fee Transferred	2026-06-08 06:05
Second Decision by Editor	2026-06-23 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-23 03:45
Articles in Press	2026-06-23 03:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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