Publication Name	World Journal of Hepatology
Manuscript ID	119664
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Smoking-induced liver injury and related diseases: Molecular mechanisms, pathogenic amplification, and clinical implications
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Wen, Tian-Yi Xue, Yan-Hui Yang, Yan-Pei Mai, Qin-Shuo Wang, Xiao-Xiao Wang, Dong-Bo Chen, Hong-Song Chen and Zi-Xing Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82570754 Peking University People’s Hospital Scientific Research Development Funds RS2024-06
Corresponding Author	Zi-Xing Wang, Assistant Professor, PhD, Peking University Hepatology Institute, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. wangzixing@pkuph.edu.cn
Key Words	Smoking; Hepatic disease; Liver injury; Chronic liver disease progression; Smoking cessation
Core Tip	Cigarette smoking is an underrecognized yet independent risk factor across the spectrum of liver diseases. This review synthesizes mechanistic, epidemiologic, and genetic evidence demonstrating that smoking induces hepatocellular injury through oxidative stress, mitochondrial dysfunction, inflammation, immune dysregulation, and genotoxicity, while synergizing with viral hepatitis, metabolic dysfunction-associated steatotic liver disease, alcohol use, and other hepatic risk factors to accelerate disease progression. We also highlight the clinical implications of smoking assessment and cessation in hepatology practice and identify key knowledge gaps regarding reversibility, legacy effects, and emerging tobacco products.
Citation	Wen X, Xue TY, Yang YH, Mai YP, Wang QS, Wang XX, Chen DB, Chen HS, Wang ZX. Smoking-induced liver injury and related diseases: Molecular mechanisms, pathogenic amplification, and clinical implications. World J Hepatol 2026; In press

Received	2026-02-05 01:41
Peer-Review Started	2026-02-05 01:44
First Decision by Editorial Office Director	2026-02-13 08:30
Return for Revision	2026-02-16 00:42
Revised	2026-03-01 11:13
Publication Fee Transferred	2026-03-02 12:16
Second Decision by Editor	2026-05-19 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-19 09:10
Articles in Press	2026-05-19 09:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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