Publication Name	World Journal of Gastroenterology
Manuscript ID	119668
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Efficacy of 7-day and 14-day potassium-competitive acid blocker-based bismuth-containing quadruple regimen for Helicobacter pylori infection
Manuscript Source	Unsolicited Manuscript
All Author List	Chang Kyo Oh, Hyun Lim, Jin Hee Noh, Eun Jeong Gong, Seung In Seo, Chang Seok Bang, Yu Jin Kim, Woon Geon Shin, Jin Bae Kim, Hyun Joo Jang and Gwang Ho Baik
Funding Agency and Grant Number	Funding Agency Grant Number HK inno.N, Republic of Korea No. KCAB_017
Corresponding Author	Hyun Lim, MD, PhD, Department of Gastroenterology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-Ro 170-Gil, Dongan-Gu, Anyang 14068, South Korea. hlim77@hallym.or.kr
Key Words	Helicobacter pylori; Potassium-competitive acid blockers; Proton pump inhibitors; Bismuth-containing quadruple therapy; Bismuth-metronidazole; Tetracycline
Core Tip	Bismuth-containing quadruple therapy is recommended as first-line treatment for Helicobacter pylori in regions with high clarithromycin resistance, yet the optimal acid suppressant and treatment duration remain unclear. This multicenter randomized trial is the study to evaluate tegoprazan, a potassium-competitive acid blocker, within a bismuth-metronidazole-tetracycline quadruple regimen. The 14-day tegoprazan-based regimen achieved non-inferior eradication compared with the conventional 14-day proton pump inhibitor-based regimen, whereas the 7-day regimen did not. These results highlight that tegoprazan-based bismuth quadruple therapy requires a 14-day duration to ensure adequate eradication efficacy.
Citation	Oh CK, Lim H, Noh JH, Gong EJ, Seo SI, Bang CS, Kim YJ, Shin WG, Kim JB, Jang HJ, Baik GH. Efficacy of 7-day and 14-day potassium-competitive acid blocker-based bismuth-containing quadruple regimen for Helicobacter pylori infection. World J Gastroenterol 2026; In press

Received	2026-02-03 01:56
Peer-Review Started	2026-02-03 01:57
First Decision by Editorial Office Director	2026-03-04 09:09
Return for Revision	2026-03-04 09:09
Revised	2026-03-17 02:06
Publication Fee Transferred	2026-03-25 10:14
Second Decision by Editor	2026-05-27 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-27 07:05
Articles in Press	2026-05-27 07:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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