Publication Name	World Journal of Gastroenterology
Manuscript ID	119677
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Microbiota signatures and genetic risk in pediatric celiac disease
Manuscript Source	Invited Manuscript
All Author List	Ruveyda Akcin, Suat Saribas and Bekir Kocazeybek
Funding Agency and Grant Number
Corresponding Author	Bekir Kocazeybek, Professor, Department of Medical Microbiology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Kocamustafapaşa St No. 53, Istanbul 34098, Türkiye. bzeybek@istanbul.edu.tr
Key Words	Gut microbiota; Human leukocyte antigen; Mycobiome; Pediatric celiac disease; Virome
Core Tip	Pediatric celiac disease cannot be explained by host genetics alone. Although human leukocyte antigen-DQ2 and human leukocyte antigen-DQ8 are necessary risk factors in most patients, they do not fully account for disease onset or clinical heterogeneity. Current evidence suggests that the gut microbiota, including bacterial, fungal, and viral communities, may act as a dynamic interface between genetic predisposition and environmental exposures. Longitudinal and functional studies in at-risk children may help define early microbial signatures and improve future risk stratification.
Citation	Akcin R, Saribas S, Kocazeybek B. Microbiota signatures and genetic risk in pediatric celiac disease. World J Gastroenterol 2026; In press

Received	2026-02-03 01:03
Peer-Review Started	2026-02-03 01:06
First Decision by Editorial Office Director	2026-02-28 08:16
Return for Revision	2026-02-28 08:16
Revised	2026-04-22 11:29
Publication Fee Transferred
Second Decision by Editor	2026-05-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-22 06:36
Articles in Press	2026-05-22 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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