Publication Name	World Journal of Psychiatry
Manuscript ID	119686
Country	India

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association
Manuscript Source	Invited Manuscript
All Author List	Manjeet Kumar Goyal, Omesh Goyal, Praneet Wander, Jaskirat Kaur, Gargi Prashar, Prerna Goyal and Ajit Sood
Funding Agency and Grant Number
Corresponding Author	Omesh Goyal, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. goyalomesh@yahoo.co.in
Key Words	Anxiety; Depression; Functional bowel disorders; Functional constipation; Functional dyspepsia; Irritable bowel syndrome; Overlap; Quality of life; Rome IV criteria
Core Tip	Psychological comorbidities are highly prevalent in disorders of gut-brain interaction (DGBIs), particularly among patients with overlapping syndromes. In this large Rome IV-based cohort, anxiety and depression affected nearly two-thirds and one-third of patients, respectively, with substantially worse quality of life in overlap DGBIs. Notably, gastrointestinal symptoms preceded the onset of anxiety and depression in most cases, supporting a predominant gut-to-brain trajectory. These findings emphasize the need for early identification and proactive management of DGBIs, alongside integrated gut-brain care strategies, to potentially mitigate subsequent psychological morbidity.
Citation	Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut-brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; In press

Received	2026-02-03 00:58
Peer-Review Started	2026-02-03 00:58
First Decision by Editorial Office Director	2026-03-04 07:53
Return for Revision	2026-03-04 07:53
Revised	2026-03-09 19:31
Publication Fee Transferred
Second Decision by Editor	2026-04-08 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 05:51
Articles in Press	2026-04-08 05:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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