Publication Name	World Journal of Gastroenterology
Manuscript ID	119697
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Biological interpretation of baseline hepatitis B surface antigen and cirrhosis in determining interferon treatment duration
Manuscript Source	Invited Manuscript
All Author List	Ling-Feng Zou, Shao-Ding Yu, Yan Luo and Cheng-Long Wang
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) 2023MSXM060
Corresponding Author	Cheng-Long Wang, MD, PhD, Department of Pathology, Chongqing Traditional Chinese Medicine Hospital, No. 6 Panxi 7 Branch Road, Liangjiang New Area, Chongqing 400021, China. qq171909771@gmail.com
Key Words	Chronic hepatitis B; Hepatitis B surface antigen; Sinusoidal capillarization; Liver sinusoidal endothelial cells; Cirrhosis
Core Tip	We interpret baseline hepatitis B surface antigen and cirrhosis as pathological surrogates for the virus-host equilibrium. High hepatitis B surface antigen may indicate an entrenched viral reservoir and may be associated with persistent antigenic pressure that contributes to antiviral immune dysfunction, while cirrhotic vascular remodeling may reduce the efficiency of immune surveillance. Consequently, extended interferon therapy may be more frequently required in patients with these biological and structural constraints.
Citation	Zou LF, Yu SD, Luo Y, Wang CL. Biological interpretation of baseline hepatitis B surface antigen and cirrhosis in determining interferon treatment duration. World J Gastroenterol 2026; In press

Received	2026-02-03 01:25
Peer-Review Started	2026-02-03 01:28
First Decision by Editorial Office Director	2026-03-12 08:57
Return for Revision	2026-03-12 08:57
Revised	2026-03-26 09:02
Publication Fee Transferred
Second Decision by Editor	2026-04-13 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-13 10:36
Articles in Press	2026-04-13 10:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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