Publication Name	World Journal of Clinical Cases
Manuscript ID	119700
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Meta-Analysis
Article Title	Liquid or soft-gel levothyroxine vs tablet levothyroxine in athyreotic adults after total thyroidectomy: Systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Muhammad Farhan, Tirath Patel, Mohammed Al-Hadi Naseer Obais, Hassan Taslimi, Maira Hanif, Kawish Khalid, Ali Qaqour, Juman Waisi, Hafsa Khalid, Aalaa Hasan Abdulla Abbas Husain, Ruba Hammouda, Safi Ullah Khan, Bhumi Daishik Patel, Nana Sardarova and Ayoola Awosika
Funding Agency and Grant Number
Corresponding Author	Ayoola Awosika, MD, Department of Family and Community Medicine, University of Illinois College of Medicine Peoria, 1 Illini Drive, Bloomington, IL 61601, United States. ayoolaawosika@yahoo.com
Key Words	Levothyroxine formulations; Thyroidectomy; Thyroid-stimulating hormone level outcomes; Thyroid hormone replacement; Triiodothyronine
Core Tip	Levothyroxine (LT4) is one of the most widely prescribed medications for hypothyroidism globally; however, its narrow therapeutic index requires careful dose individualization to avoid the risks of iatrogenic hyperthyroidism or hypothyroidism. In this systematic review and meta-analysis of athyreotic adults following total thyroidectomy, liquid or soft-gel LT4 was associated with significantly lower thyroid-stimulating hormone levels and modest but consistent increases in circulating total thyroxine and triiodothyronine levels compared with tablet formulations. These findings support a personalized approach to LT4 therapy, rather than the routine substitution of formulations, in all thyroidectomized patients.
Citation	Farhan M, Patel T, Obais MAHN, Taslimi H, Hanif M, Khalid K, Qaqour A, Waisi J, Khalid H, Abbas Husain AHA, Hammouda R, Khan SU, Patel BD, Sardarova N, Awosika A. Liquid or soft-gel levothyroxine vs tablet levothyroxine in athyreotic adults after total thyroidectomy: Systematic review and meta-analysis. World J Clin Cases 2026; In press

Received	2026-02-05 01:02
Peer-Review Started	2026-02-05 01:05
First Decision by Editorial Office Director	2026-02-12 08:10
Return for Revision	2026-02-12 08:10
Revised	2026-02-23 04:13
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 06:44
Articles in Press	2026-04-01 06:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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