Publication Name	World Journal of Gastroenterology
Manuscript ID	119706
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Risk factors for low-level viremia in tenofovir disoproxil fumarate-treated chronic hepatitis B patients with advanced hepatic fibrosis/compensated cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Run-Ling Zhang, Hai-Ying Zhang, Yu-Yuan Jia, Zhen-Yu Wang, Feng Liu, Hong-Song Chen and Hui-Ying Rao
Funding Agency and Grant Number
Corresponding Author	Hui-Ying Rao, Professor, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, No. 133, Fuchengmennei Street, Xicheng District, Beijing 100044, China. rao.huiying@163.com
Key Words	Low-level viremia; Nucleos(t)ide analogs; Chronic hepatitis B; Compensated cirrhosis; Risk factor
Core Tip	Our retrospective study enrolled 141 chronic hepatitis B (CHB) patients with advanced hepatic fibrosis/compensated cirrhosis undergoing tenofovir disoproxil fumarate therapy, with the incidence of low-level viremia (LLV) reaching 17.0% at 48 weeks of treatment. Multivariate logistic regression analysis confirmed that baseline hepatitis B virus DNA ≥ 7.0 Log10 IU/mL was an independent high-risk factor for LLV development. This finding provides comprehensive clinical evidence for early risk stratification and individualized intervention of LLV in this specific high-risk CHB population.
Citation	Zhang RL, Zhang HY, Jia YY, Wang ZY, Liu F, Chen HS, Rao HY. Risk factors for low-level viremia in tenofovir disoproxil fumarate-treated chronic hepatitis B patients with advanced hepatic fibrosis/compensated cirrhosis. World J Gastroenterol 2026; In press

Received	2026-02-06 02:23
Peer-Review Started	2026-02-06 02:25
First Decision by Editorial Office Director	2026-03-06 09:28
Return for Revision	2026-03-06 09:28
Revised	2026-03-16 04:12
Publication Fee Transferred	2026-03-20 08:36
Second Decision by Editor	2026-04-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-15 09:07
Articles in Press	2026-04-15 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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