Publication Name	World Journal of Gastroenterology
Manuscript ID	119736
DOI	10.3748/wjg.119736
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Predictive model to identify patients requiring extended interferon therapy in chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	Cheng-Yuan Tsai and Ching-Shan Huang
Funding Agency and Grant Number
Corresponding Author	Ching-Shan Huang, Professor, Department of Clinical Pathology, Cathay General Hospital, No. 280, Sec 4, Ren Ai Road, Taipei 10630, Taiwan. ching.shan.h@gmail.com
Key Words	Chronic hepatitis B; Cirrhosis; Hepatitis B surface antigen; Nucleos(t)ide analog; Pegylated interferon α-2b
Core Tip	Yan et al published a study in the World Journal of Gastroenterology regarding interferon therapy for chronic hepatitis B clearance that warrants broad attention. In this editorial, we review their work and contextualize their findings within the scope of similar English-language publications in PubMed. A novel finding of their study is that stable discriminatory ability was noted for both the training cohort (area under the receiver operating characteristic curve = 0.83) and the validation cohort (area under the receiver operating characteristic curve = 0.81), with predictive efficacy unaffected by subgroup characteristics. We also discuss the limitations of their study and address its potential clinical implications.
Citation	Tsai CY, Huang CS. Predictive model to identify patients requiring extended interferon therapy in chronic hepatitis B. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.119736

Received	2026-02-04 00:50
Peer-Review Started	2026-02-04 00:57
First Decision by Editorial Office Director	2026-04-03 07:37
Return for Revision	2026-04-03 07:37
Revised	2026-04-18 08:15
Publication Fee Transferred
Second Decision by Editor	2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-12 07:30
Articles in Press	2026-06-12 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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