Publication Name	World Journal of Transplantation
Manuscript ID	119737
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Impact of dexmedetomidine administration on serum creatinine levels following liver transplantation: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Sabah Kulsum, Sajjad Ahmed Khan, Dushyant Singh Dahiya, Hadeera Ali, Umar Hayat, Mohamed Khalaf and Hassam Ali
Funding Agency and Grant Number
Corresponding Author	Hassam Ali, Division of Gastroenterology, Hepatology and Nutrition, East Carolina University/Brody School of Medicine, 2100 Statonsburg Road, Greenville, NC 27858, United States. hassamali155@gmail.com
Key Words	Dexmedetomidine; Liver transplantation; Acute kidney injury; Serum creatinine; Renal protection; Preoperative/perioperative care; Systematic review; Meta-analysis
Core Tip	Preoperative/perioperative dexmedetomidine administration was associated with a modest reduction in postoperative serum creatinine following liver transplantation; however, this effect did not translate into a consistent reduction in clinically meaningful renal outcomes such as acute kidney injury. Significant heterogeneity in creatinine measurement timing, outcome definitions, and analytical approaches across studies further limits interpretation, highlighting the need for standardized protocols and trials focused on clinically relevant renal endpoints.
Citation	Kulsum S, Khan SA, Dahiya DS, Ali H, Hayat U, Khalaf M, Ali H. Impact of preoperative/perioperative dexmedetomidine administration on serum creatinine levels following liver transplantation: A systematic review and meta-analysis. World J Transplant 2026; In press

Received	2026-02-04 00:48
Peer-Review Started	2026-02-04 00:57
First Decision by Editorial Office Director	2026-02-25 08:06
Return for Revision	2026-02-25 08:06
Revised	2026-03-26 22:26
Publication Fee Transferred
Second Decision by Editor	2026-04-13 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-13 09:37
Articles in Press	2026-04-13 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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