Publication Name	World Journal of Diabetes
Manuscript ID	119741
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Nicotinamide mononucleotide-loaded thermosensitive hydrogel promotes diabetic wound healing via antibacterial and antioxidant synergy in a mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Fei Peng, Yang-Yang Li, Yuan Tang, Shang-Xue Sun, Yu-Qi Zhu, Xin-Yin Zhang and Huan-Zhang Zhu
Funding Agency and Grant Number
Corresponding Author	Huan-Zhang Zhu, Academic Fellow, School of Life Sciences, Fudan University, No. 2005 Songhu Road, Xinjiangwancheng Street, Yangpu District, Shanghai 200433, China. hzzhu@fudan.edu.cn
Key Words	Diabetic ulcer; Thermosensitive composite hydrogel; Hydrogel dressing; Nicotinamide mononucleotide; Polyhexamethylene biguanide
Core Tip	In this study, a thermosensitive Pluronic F127/polyhexamethylene biguanide composite hydrogel loaded with antioxidant nicotinamide mononucleotide was prepared, which showed sustained strong antibacterial and antioxidant properties and favorable biosafety. In vitro, hydrogel inhibited bacteria, and boosted cell migration and angiogenesis. In mouse models, it markedly accelerated diabetic ulcer healing via faster re-epithelialization, reduced inflammation, elevated collagen deposition and angiogenesis, as well as upregulating vascular endothelial growth factor and transforming growth factor-β1. This hydrogel is a safe, effective novel dressing for clinical diabetic ulcer treatment.
Citation	Peng F, Li YY, Tang Y, Sun SX, Zhu YQ, Zhang XY, Zhu HZ. Nicotinamide mononucleotide-loaded thermosensitive hydrogel promotes diabetic wound healing via antibacterial and antioxidant synergy in a mouse model. World J Diabetes 2026; In press

Received	2026-02-10 09:37
Peer-Review Started	2026-02-11 02:56
First Decision by Editorial Office Director	2026-03-05 08:50
Return for Revision	2026-03-05 08:50
Revised	2026-04-01 08:34
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 09:30
Articles in Press	2026-05-18 09:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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