Publication Name	World Journal of Gastroenterology
Manuscript ID	119744
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Di Ma, Wan-Jing Chen, Ke-Xun Yu, Hui-Zhen Wang and Yong-Xiang Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82372646 Key Project of Scientific Research Project of Anhui Provincial Department of Education, China 2023AH053334
Corresponding Author	Yong-Xiang Li, Chief, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. liyongxiang@ahmu.edu.cn
Key Words	Gastric cancer; Ferroptosis; Helicobacter pylori; Digestion; Nuclear factor kappa B
Core Tip	In this study, Helicobacter pylori co-cultured with the stomach cancer cell line AGS was subjected to transcriptome sequencing. The findings showed that Helicobacter pylori increase the transcription of epidermal growth factor receptor pathway substrate 8-like protein 3 via activating the nuclear factor kappa B signaling pathway. By participating in glutathione metabolism and interacting with solute carrier family 7 member 11 and glutathione peroxidase 4, epidermal growth factor receptor pathway substrate 8-like protein 3 plays a crucial function in preventing ferroptosis in gastric cancer. This process promotes the growth and spread of stomach cancer.
Citation	Ma MD, Chen WJ, Yu KX, Wang HZ, Li YX. Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis. World J Gastroenterol 2026; In press

Received	2026-02-05 01:43
Peer-Review Started	2026-02-05 01:44
First Decision by Editorial Office Director	2026-03-02 09:04
Return for Revision	2026-03-02 09:04
Revised	2026-03-09 14:26
Publication Fee Transferred	2026-03-12 16:57
Second Decision by Editor	2026-04-28 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-28 09:14
Articles in Press	2026-04-28 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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