Publication Name	World Journal of Clinical Cases
Manuscript ID	119746
Country	India

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Pathophysiology of ocular manifestations in Wilson’s disease and its management
Manuscript Source	Invited Manuscript
All Author List	Manpreet Kaur, Shweta Walia, Arvind Kumar Morya, Puja Hingorani Bang, Sarita Aggarwal, Parul Chawla Gupta, Rutuja Nagare, Hemlata Udenia, Srishti Khullar and Rannusha Morya
Funding Agency and Grant Number
Corresponding Author	Arvind Kumar Morya, Additional Professor, Consultant, Principal Investigator, Researcher, Senior Researcher, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com
Key Words	Wilson disease; Ocular manifestation; Kayser-Fleischer ring; Sunflower cataract; Copper metabolism
Core Tip	Autosomal recessive ATP7B gene dysfunction in Wilson’s disease causes sequestered copper in hepatocytes to effect oxidative damage and necrosis, subsequently releasing into systemic circulation and reaching the eyes, brain, and kidneys. Free copper binds reversibly with metallothionein protein in the Descemet’s, causing Kayser-Fleischer rings (and anterior capsule, causing rare non-vision-threatening sunflower cataracts)-serving as clinical severity biomarkers for diagnosis and treatment compliance/responsiveness, especially among symptomatic adults. Gonioscopy, anterior segment optical coherence tomography, and confocal imaging strengthen the ophthalmologist’s diagnostic advantage over slit-lamp alone. Children with a family history of consanguinity need early screening due to subtle biochemical abnormalities and nonspecific neurological, behavioral, renal, and hematological symptoms, but they have a good chelation response and yet the possibility of fulminant complications.
Citation	Kaur M, Walia S, Morya AK, Bang PH, Aggarwal S, Gupta PC, Nagare R, Udenia H, Khullar S, Morya R. Pathophysiology of ocular manifestations in Wilson’s disease and its management. World J Clin Cases 2026; In press

Received	2026-02-05 01:07
Peer-Review Started	2026-02-05 01:07
First Decision by Editorial Office Director	2026-02-27 08:49
Return for Revision	2026-02-27 08:49
Revised	2026-03-07 05:04
Publication Fee Transferred
Second Decision by Editor	2026-03-30 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-30 05:58
Articles in Press	2026-03-30 05:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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