Publication Name	World Journal of Stem Cells
Manuscript ID	119749
DOI	10.4252/wjsc.119749
Country	China

Category	Cell Biology
Manuscript Type	Retrospective Study
Article Title	Circulating stem/progenitor cell biomarkers and prognosis in critically ill patients with gastrointestinal bleeding
Manuscript Source	Unsolicited Manuscript
All Author List	Bin Xie, Jin Zhang, Yan-Hua Wen and Hui-Feng Zhao
Funding Agency and Grant Number
Corresponding Author	Hui-Feng Zhao, MD, Intensive Care Unit, Jiashan First People’s Hospital, No. 1218 Tiyu South Road, Luoxing Street, Jiashan 314100, Zhejiang Province, China. zhaohf9945@163.com
Key Words	Critical illness; Gastrointestinal bleeding; Circulating stem/progenitor cells; Endothelial progenitor cells; Flow cytometry; Prognostic model
Core Tip	In this retrospective of intensive care unit patients with gastrointestinal bleeding, early circulating endothelial progenitor cell (CD34+KDR+) levels were lower in patients who died within 28 days and remained associated with mortality after adjusting for clinical variables. The endothelial progenitor cell-clinical model showed moderate discrimination and high specificity, but limited sensitivity; therefore, it should not be interpreted as a standalone early warning tool for high-risk screening. Its current value is mainly hypothesis-generating and may complement organ dysfunction scores and help identify patients with relatively low predicted risk, pending external validation and standardized flow cytometry workflows.
Citation	Xie B, Zhang J, Wen YH, Zhao HF. Circulating stem/progenitor cell biomarkers and prognosis in critically ill patients with gastrointestinal bleeding. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.119749
PDF	119749-in-press.pdf

Received	2026-04-08 09:52
Peer-Review Started	2026-04-08 09:53
First Decision by Editorial Office Director	2026-04-21 09:13
Return for Revision	2026-04-21 09:13
Revised	2026-05-07 08:21
Publication Fee Transferred
Second Decision by Editor	2026-06-02 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 06:50
Articles in Press	2026-06-09 06:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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