Publication Name	World Journal of Diabetes
Manuscript ID	119756
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Type 2 diabetes, sex and metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Amedeo Lonardo, Mohamad Jamalinia and Ralf Weiskirchen
Funding Agency and Grant Number
Corresponding Author	Amedeo Lonardo, Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena (2023), Via Giardini 1355, Modena 41126, Provincia di Modena, Italy. a.lonardo@libero.it
Key Words	Steatotic liver disease; Metabolic dysfunction-associated steatotic liver disease; Metabolic syndrome; Sex; Type 2 diabetes
Core Tip	Animal models indicate that males are more susceptible to obesity and metabolic disorders. Men, especially those in middle age, exhibit higher rates of type 2 diabetes. Sex also influences risk factors for atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease (MASLD). Among individuals with diabetes, women’s risk for ASCVD and MASLD increases over time as the protective effects of sex hormones diminish. While estradiol has demonstrated protective properties, further investigation into the roles of sex chromosomes and epigenetic factors is warranted. Recognizing these distinctions is essential for advancing precision medicine and optimizing diabetes management.
Citation	Lonardo A, Jamalinia M, Weiskirchen R. Type 2 diabetes, sex and metabolic dysfunction-associated steatotic liver disease. World J Diabetes 2026; In press

Received	2026-02-05 00:59
Peer-Review Started	2026-02-05 01:00
First Decision by Editorial Office Director	2026-02-25 09:01
Return for Revision	2026-02-25 13:12
Revised	2026-02-28 22:57
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-30 06:28
Articles in Press	2026-03-30 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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