Publication Name	World Journal of Diabetes
Manuscript ID	119760
DOI	10.4239/wjd.119760
Country	China

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Stem cells-derived islet transplantation toward clinical translation: Divergent strategies and convergent objectives
Manuscript Source	Unsolicited Manuscript
All Author List	Duo-Wen He, Fu-Rong Zhang, Hong-Xi Zhang, Shu-Yan Xiao, Xiao-Yan Bi, Yi-Man Wang, Ru-Lan Wang, Yi-Xian Lu, Hao Yin and Tuo Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82595903 National Natural Science Foundation of China 82470935 National Natural Science Foundation of China 82470838 National Key Research and Development Program of China (Disruptive Technology Innovation Special Project) 2025YFF1501700
Corresponding Author	Tuo Li, Professor, Department of Endocrinology, Shanghai Changzheng Hospital, No. 415 Fengyang Road, Shanghai 200433, China. dr.lituo@smmu.edu.cn
Key Words	Stem cells-derived islets; Islet transplantation; Diabetes mellitus; Pluripotent stem cells; Regenerative medicine; Immunomodulation
Core Tip	This review systematically compared leading stem cells-derived islet transplantation strategies, including autologous and allogeneic approaches from key research centers. It highlighted the trade-offs among immunogenicity, scalability, and personalization, and proposed future integrative solutions combining gene editing, localized immunomodulation, and cryopreservation advances to overcome current barriers toward a functional cure for diabetes.
Citation	He DW, Zhang FR, Zhang HX, Xiao SY, Bi XY, Wang YM, Wang RL, Lu YX, Yin H, Li T. Stem cells-derived islet transplantation toward clinical translation: Divergent strategies and convergent objectives. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.119760

Received	2026-02-06 00:32
Peer-Review Started	2026-02-06 09:38
First Decision by Editorial Office Director	2026-02-25 07:48
Return for Revision	2026-02-25 07:48
Revised	2026-03-08 12:11
Publication Fee Transferred	2026-03-09 17:13
Second Decision by Editor	2026-06-01 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-03 08:57
Articles in Press	2026-06-03 08:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com