Publication Name	World Journal of Psychiatry
Manuscript ID	119768
Country	China

Category	Psychiatry
Manuscript Type	Correspondence
Article Title	Letter to the Editor: From discovery to application: Serum 5-hydroxytryptamine for early screening of Parkinson’s complications still faces key challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Ye-Xiang Chen
Funding Agency and Grant Number
Corresponding Author	Ye-Xiang Chen, Academic Fellow, PhD, Postdoctoral Fellow, Department of Pharmacology, College of Medicine, Jiaxing University, No. 899 Guangqiong Road, Jiaxing 314001, Zhejiang Province, China. yexiangchen@zcmu.edu.cn
Key Words	Parkinson‘s disease; 5-hydroxytryptamine; Biomarker; Motor dysfunction; Depression
Core Tip	Reduced serum 5-hydroxytryptamine levels may indicate an increased risk of both dyskinesia and depression in patients with Parkinson’s disease, suggesting its potential role as a unified screening marker for these complications. However, due to limited validation, as well as the absence of robust longitudinal data and standardized assessment protocols, its clinical applicability remains constrained. Therefore, it should be considered only as an adjunctive biomarker rather than a definitive diagnostic or prognostic indicator at the present stage.
Citation	Chen YX. Letter to the Editor: From discovery to application: Serum 5-hydroxytryptamine for early screening of Parkinson’s complications still faces key challenges. World J Psychiatry 2026; In press

Received	2026-02-05 01:25
Peer-Review Started	2026-02-05 01:27
First Decision by Editorial Office Director	2026-02-28 06:34
Return for Revision	2026-02-28 06:34
Revised	2026-03-01 12:30
Publication Fee Transferred
Second Decision by Editor	2026-04-02 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 05:02
Articles in Press	2026-04-02 05:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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