Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	119778
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Precision immunotherapy in oesophageal squamous cell carcinoma: Molecular pathogenesis and checkpoint inhibitor response prediction
Manuscript Source	Invited Manuscript
All Author List	Meer M Chisthi, Sindhu Viswanath and Krishnakumar G Kuttanchettiyar
Funding Agency and Grant Number
Corresponding Author	Meer M Chisthi, Associate Professor, Department of General Surgery, Government Medical College Kollam, Parippally, Kollam, Parippally 691574, Kerala, India. meerchisthi.m@tmc.kerala.gov.in
Key Words	Oesophageal squamous cell carcinoma; Precision immunotherapy; Immune checkpoint inhibitors; Molecular pathogenesis; Predictive biomarkers; Tumour microenvironment
Core Tip	Precision immunotherapy is transforming the management of oesophageal squamous cell carcinoma (ESCC). This review synthesizes current knowledge on the molecular drivers of ESCC and the complex tumour-immune interactions that dictate response to immune checkpoint inhibitors (ICIs). We detail established and emerging biomarkers-such as programmed death-ligand 1 expression, tumour mutational burden, and circulating tumour DNA-for predicting ICI efficacy. The discussion extends to mechanisms of resistance and future directions, including novel immune targets and multi-omics integration for personalized treatment strategies, aiming to guide clinicians and researchers toward more effective, tailored immunotherapeutic interventions.
Citation	Chisthi MM, Viswanath S, Kuttanchettiyar KG. Precision immunotherapy in oesophageal squamous cell carcinoma: Molecular pathogenesis and checkpoint inhibitor response prediction. World J Gastrointest Pharmacol Ther 2026; In press

Received	2026-02-10 02:22
Peer-Review Started	2026-02-10 02:23
First Decision by Editorial Office Director	2026-02-27 08:55
Return for Revision	2026-02-27 08:55
Revised	2026-03-03 04:14
Publication Fee Transferred
Second Decision by Editor	2026-04-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 07:30
Articles in Press	2026-04-02 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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