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Articles in Press
5/26/2026 4:24:03 AM | Browse: 4 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Berberine as a dual-target therapeutic for ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dharmendra K Maurya and Prashasti Sharma |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dharmendra K Maurya, PhD, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-Block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in |
| Key Words |
Ulcerative colitis; Inflammatory bowel disease; Berberine; Traditional Chinese medicine; Fecal microbiota transplantation; Gasdermin D |
| Core Tip |
Berberine ameliorates ulcerative colitis by modulating gut microbiota dysbiosis and inhibiting gasdermin D-mediated pyroptosis. It enriches beneficial taxa producing short-chain fatty acids, suppresses proinflammatory cytokines (e.g., interleukin-1β, tumor necrosis factor-α), and restores epithelial tight junctions (zonula occludens-1, claudin-1). Preclinical dextran sulfate sodium mouse models demonstrate reduced inflammation, histological damage, and clinical scores. |
| Citation |
Maurya DK, Sharma P. Berberine as a dual-target therapeutic for ulcerative colitis. World J Gastroenterol 2026; In press |
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Received |
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2026-02-09 01:23 |
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Peer-Review Started |
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2026-02-09 01:24 |
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First Decision by Editorial Office Director |
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2026-02-25 09:09 |
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Return for Revision |
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2026-02-25 09:09 |
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Revised |
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2026-03-10 11:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-26 04:24 |
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Articles in Press |
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2026-05-26 04:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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