Publication Name	World Journal of Critical Care Medicine
Manuscript ID	119806
Country	United States

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Physiology-guided mechanical ventilation: Monitoring, proportional assist, and bounded automation
Manuscript Source	Invited Manuscript
All Author List	Robel Yohannes, Gavin Jeffries, Shervin Eskandari, Jacob Calamaro, Nicola M Zetola and William J Healy
Funding Agency and Grant Number
Corresponding Author	William J Healy, Assistant Professor, Division of Pulmonary, Critical Care, and Sleep Medicine, Medical College of Georgia, 120 15th Street, Augusta, GA 30912, United States. wihealy@augusta.edu
Key Words	Mechanical ventilation; Critical care; Pulmonary medicine; Intensive care medicine; Ventilator management
Core Tip	Mechanical ventilation should be approached as a dynamic, patient-specific therapy rather than a fixed protocol. Integrating physiologic monitoring of respiratory effort, lung stress, and regional ventilation can help clinicians individualize support while balancing lung protection and diaphragm preservation. For example, ventilatory assist may be titrated to maintain moderate inspiratory effort rather than targeting airway pressures or tidal volume alone. Emerging monitoring, proportional assist modes, and bounded automation are best viewed as tools that augment physiologic assessment while preserving clinician judgment in the management of critically ill patients.
Citation	Yohannes R, Jeffries G, Eskandari S, Calamaro J, Zetola NM, Healy WJ. Physiology-guided mechanical ventilation: Monitoring, proportional assist, and bounded automation. World J Crit Care Med 2026; In press

Received	2026-02-06 00:45
Peer-Review Started	2026-02-06 00:56
First Decision by Editorial Office Director	2026-02-12 08:28
Return for Revision	2026-02-12 08:28
Revised	2026-03-05 03:34
Publication Fee Transferred
Second Decision by Editor	2026-05-14 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 07:25
Articles in Press	2026-05-14 07:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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