Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119834
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	MCM10 promotes hepatocellular carcinoma progression via regulating cyclin D1
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Ru Chen, Gang Wang, Long-Jun He, Huo-Wang Ye, Li-Feng Wang, Dan-Dan Zou, Mei-Qian Wang, Hui-Wen Xie, Sen-Lin Zhu and Xin-Ying Wang
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Guangzhou 2024A04J4877 Clinical Research Special Fund of Guangdong Medical Association 2024HY-A5018 the President Foundation of Zhujiang Hospital, Southern Medical University Yzjj2022qn13 Shandong Provincial Natural Science Foundation ZR2024QH338
Corresponding Author	Xin-Ying Wang, Department of Gastroenterology, Zhujiang Hospital of Southern Medical University, No. 253 Gongye Road, Guangzhou 510280, Guangdong Province, China. helenwxy@smu.edu.cn
Key Words	MCM10; Hepatocellular carcinoma; Proliferation; Tumorigenesis; Cyclin D1
Core Tip	DNA replication constitutes a core mechanism underlying cellular proliferation, whereas unrestrained DNA replication has been identified as a pivotal driving force in tumorigenesis. This study aimed to explore the biological function of the conserved replication regulator MCM10 in hepatocellular carcinoma (HCC). Upregulated expression of MCM10 was demonstrated to correlate with adverse clinicopathological features and inferior survival prognosis. Silencing of MCM10 significantly diminished the proliferative ability and oncogenic potential of HCC cells. Cyclin D1 was further confirmed to be modulated by MCM10, and the combined evaluation of MCM10 and cyclin D1 showed superior prognostic performance in HCC patients. These findings underscore the synergistic value of the MCM10 cyclin D1 molecular axis as a combined biomarker panel for prognostic prediction in HCC.
Citation	Chen YR, Wang G, He LJ, Ye HW, Wang LF, Zou DD, Wang MQ, Xie HW, Zhu SL, Wang XY. MCM10 promotes hepatocellular carcinoma progression via regulating cyclin D1. World J Gastrointest Oncol 2026; In press

Received	2026-02-07 03:55
Peer-Review Started	2026-02-07 03:55
First Decision by Editorial Office Director	2026-02-13 07:08
Return for Revision	2026-02-13 07:08
Revised	2026-02-19 05:56
Publication Fee Transferred	2026-02-25 13:25
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 05:30
Articles in Press	2026-05-06 05:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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