Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	119840
DOI	10.5409/wjcp.119840
Country	India

Category	Anesthesiology
Manuscript Type	Evidence Review
Article Title	Chronic post-surgical pain in children: Current evidence and clinical perspectives
Manuscript Source	Invited Manuscript
All Author List	Poonam Godhwal, Anju Gupta, Aarzoo Sirohi and Nishkarsh Gupta
Funding Agency and Grant Number
Corresponding Author	Nishkarsh Gupta, Department of Onco-Anaesthesia and Palliative Medicine, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Room No. 139 FF IRCH, New Delhi 110029, Delhi, India. drnishkarsh@rediffmail.com
Key Words	Chronic post-surgical pain; Children; Surgery; Perioperative; Pain; Regional
Core Tip	The chronic postsurgical pain may occur in up to 80% in the pediatric population. This pain is more severe after high-risk surgeries, such as spine surgery, hernia repair, and thoracotomy. Potential risk factors in the pediatric population include psychosocial behaviors, preexisting pain, postsurgical pain intensity, and type of surgery. Proposed pathophysiological mechanisms include a proinflammatory state after surgery, leading to altered peripheral and central sensitization, genomic factors, epigenetic modifications, and altered brain physiology in chronic pain. Preoperative protocolized analgesic strategies, cognitive behavioral therapy, and acupuncture have been tried with varied success rates. There is a significant knowledge gap, which we have tried to address in this review.
Citation	Godhwal P, Gupta A, Sirohi A, Gupta N. Chronic post-surgical pain in children: Current evidence and clinical perspectives. World J Clin Pediatr 2026; In press DOI: https://doi.org/10.5409/wjcp.119840

Received	2026-02-07 03:06
Peer-Review Started	2026-02-07 03:07
First Decision by Editorial Office Director	2026-02-27 08:58
Return for Revision	2026-02-27 08:58
Revised	2026-03-17 17:48
Publication Fee Transferred
Second Decision by Editor	2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-12 03:41
Articles in Press	2026-06-12 03:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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