Publication Name	World Journal of Gastroenterology
Manuscript ID	119857
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Evaluating large language models in Helicobacter pylori-related question answering: From knowledge tests to patient queries
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Ping Sun, Dan-Ye Niu, Ming-Kai Yuan, Li Liu, Yi Li and Han Min
Funding Agency and Grant Number	Funding Agency Grant Number Suzhou Major Disease Multicenter Clinical Research Project DZXYJ202508
Corresponding Author	Han Min, Full Professor, MD, Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 26 Daoqian Street, Gusu District, Suzhou 215000, Jiangsu Province, China. minhan1981@njmu.edu.cn
Key Words	Helicobacter pylori; Large language models; Patient education; Readability; Patient satisfaction; Clinical decision support systems; Artificial intelligence
Core Tip	This three-phase study evaluated large language models for Chinese Helicobacter pylori health-information support, progressing from multiple-choice testing to guideline-based questions and real-world patient queries. Performance was clearly task dependent: The model that performed best in structured assessments was not necessarily the most effective in patient interaction. In phase 3, DeepSeek showed better correctness, completeness, perceived readability, and patient satisfaction. These findings support multidimensional evaluation and clinician oversight before patient-facing deployment.
Citation	Sun SP, Niu DY, Yuan MK, Liu L, Li Y, Min H. Evaluating large language models in Helicobacter pylori-related question answering: From knowledge tests to patient queries. World J Gastroenterol 2026; In press

Received	2026-02-09 02:40
Peer-Review Started	2026-02-09 02:40
First Decision by Editorial Office Director	2026-02-14 07:58
Return for Revision	2026-02-14 07:58
Revised	2026-03-20 13:56
Publication Fee Transferred	2026-03-26 11:50
Second Decision by Editor	2026-05-28 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-28 11:39
Articles in Press	2026-05-28 11:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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