Publication Name	World Journal of Clinical Oncology
Manuscript ID	119864
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Integration of pathomics and single-cell omics in pancreatic ductal adenocarcinoma: Applications and clinical translation prospects
Manuscript Source	Invited Manuscript
All Author List	Xin Yan, Hong-Yu Xu, Jia-Wu Liu, Zhi-Yong Yang and Qian Zhu
Funding Agency and Grant Number
Corresponding Author	Qian Zhu, PhD, Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan 430071, Hubei Province, China. zhuqian@whu.edu.cn
Key Words	Pancreatic ductal adenocarcinoma; Pathomics; Single-cell omics; Artificial intelligence; Multimodal integration
Core Tip	This minireview systematically summarizes the progress of single-cell omics and pathomics in pancreatic ductal adenocarcinoma (PDAC) research. Single-cell omics provides deep insights into the cellular heterogeneity, tumor microenvironment, and drug-resistance mechanisms of PDAC. Pathomics employs artificial intelligence to quantitatively analyze histopathological images, enabling automated diagnosis, molecular subtyping, and prognostic evaluation. The integration of these two approaches constructs a multidimensional “morphological-molecular-spatial” perspective, which significantly advances the precision management of PDAC. Future work should focus on standardizing multi-omics techniques, building interpretable models, and promoting clinical translation to address the current therapeutic challenges in PDAC.
Citation	Yan X, Xu HY, Liu JW, Yang ZY, Zhu Q. Integration of pathomics and single-cell omics in pancreatic ductal adenocarcinoma: Applications and clinical translation prospects. World J Clin Oncol 2026; In press

Received	2026-02-09 01:18
Peer-Review Started	2026-02-09 01:21
First Decision by Editorial Office Director	2026-02-12 08:22
Return for Revision	2026-02-12 08:22
Revised	2026-02-17 19:06
Publication Fee Transferred
Second Decision by Editor	2026-03-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-16 10:48
Articles in Press	2026-03-16 10:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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