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Articles in Press
5/13/2026 6:40:16 AM | Browse: 4 | Download: 0
| Category |
Gerontology |
| Manuscript Type |
Basic Study |
| Article Title |
Enterocloster bolteae drives hyperglycemia-associated colorectal cancer proliferation via Rac/Rho-MSH6-Elongin C signaling pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Lai, Ji-Hao Xu, Yong-Jian Chen, Hong Luo, Ying Lin, Yun-Fang Yu and Qi-Kui Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81970464 |
| National Natural Science Foundation of Guangdong Province |
No. 2022A1515110529 |
| Guangdong Science and Technology Department |
No. 2024B1212030002 |
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| Corresponding Author |
Yun-Fang Yu, Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 1 Zhanqian Heng’er Road, Dongchong Town, Shanwei 516600, Guangdong Province, China. yuyf9@mail.sysu.edu.cn |
| Key Words |
Enterocloster bolteae; Colorectal cancer; Diabetes; Intestinal flora imbalance; Proliferation |
| Core Tip |
Diabetes mellitus is an established independent risk factor for colorectal cancer (CRC). We identified Enterocloster bolteae as a discriminative gut microbial signature specific to patients with diabetes mellitus-CRC. Functional pathway analysis further revealed a distinctive enrichment of carcinogenesis-related signaling pathways in this cohort, including RAC, RHO, MSH6, and Elongin C, which was subsequently validated in vitro. These findings establish a link between a diabetes-enriched gut bacterium and the activation of oncogenic pathways in CRC. |
| Citation |
Lai Y, Xu JH, Chen YJ, Luo H, Lin Y, Yu YF, Chen QK. Enterocloster bolteae drives hyperglycemia-associated colorectal cancer proliferation via Rac/Rho-MSH6-Elongin C signaling pathways. World J Gastrointest Oncol 2026; In press |
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Received |
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2026-02-27 09:12 |
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Peer-Review Started |
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2026-02-27 09:12 |
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First Decision by Editorial Office Director |
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2026-03-06 08:36 |
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Return for Revision |
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2026-03-06 08:36 |
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Revised |
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2026-03-19 03:32 |
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Publication Fee Transferred |
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2026-03-23 14:00 |
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Second Decision by Editor |
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2026-05-13 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-13 06:40 |
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Articles in Press |
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2026-05-13 06:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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