Publication Name	World Journal of Nephrology
Manuscript ID	119882
Country	India

Category	Urology & Nephrology
Manuscript Type	Case Control Study
Article Title	Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study
Manuscript Source	Invited Manuscript
All Author List	Mythri Shankar, Manju Moorthy, Aditya Shetty and Sreedhara C Gurusiddaiah
Funding Agency and Grant Number	Funding Agency Grant Number Rajiv Gandhi University of Health Sciences No. 20MED276
Corresponding Author	Mythri Shankar, Associate Professor, Department of Nephrology, Institute of Nephrourology, Victoria Hospital Campus, Bengaluru 560102, Karnataka, India. mythri.nish@gmail.com
Key Words	Immunoglobulin A nephropathy; Urinary exosomal microRNA; Non-invasive biomarker; Indian cohort; Glomerulonephritis; Kidney biopsy
Core Tip	This case-control study evaluates urinary exosomal microRNAs (miRNAs) as noninvasive biomarkers for diagnosing immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis. In biopsy-proven IgAN, healthy controls, and diverse glomerular disease controls, a NanoString-based urinary exosomal miRNA panel was profiled, followed by Least Absolute Shrinkage and Selection Operator feature selection, logistic regression, and combinatorial receiver operating characteristic analysis. A focused set of IgAN-associated miRNAs, and a minimal multi-miRNA combination, demonstrated good diagnostic performance to distinguish IgAN from both healthy individuals and other glomerular diseases, suggesting a potential future role for urine exosomal miRNA signatures in reducing reliance on invasive kidney biopsy.
Citation	Shankar M, Moorthy M, Shetty A, Gurusiddaiah SC. Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study. World J Nephrol 2026; In press

Received	2026-02-10 00:41
Peer-Review Started	2026-02-10 01:08
First Decision by Editorial Office Director	2026-02-28 06:58
Return for Revision	2026-02-28 06:58
Revised	2026-03-04 14:45
Publication Fee Transferred
Second Decision by Editor	2026-04-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-09 08:04
Articles in Press	2026-04-09 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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