Publication Name	World Journal of Stem Cells
Manuscript ID	119893
DOI	10.4252/wjsc.119893
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Opinion Review
Article Title	Bone marrow niche adaptation, leukemic stem cell persistence, and therapeutic resistance in FLT3-mutated leukemia
Manuscript Source	Invited Manuscript
All Author List	Huai-Bin Zhang, Hui-Hui Jiang, Jian-Chuan Deng and Nan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82500204 Natural Science Foundation of Chongqing CSTB2025NSCQ-GPX1181
Corresponding Author	Nan Zhang, Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing 400010, China. zhangnan@hospital.cqmu.edu.cn
Key Words	FLT3 mutation; Acute myeloid leukemia; Bone marrow microenvironment; Leukemia stem cell; Therapeutic resistance
Core Tip	FLT3-mutated leukemia remains clinically challenging because therapeutic resistance is driven not only by intrinsic oncogenic signaling, but also by adaptive interactions with the bone marrow microenvironment. This review highlights how stromal protection, chemokine-mediated retention, hypoxic support, metabolic rewiring, immune evasion, and leukemia stem cell persistence collectively promote treatment failure and relapse. It also summarizes current and emerging therapeutic strategies aimed at cotargeting FLT3 signaling, the supportive niche, and stem cell-related vulnerabilities.
Citation	Zhang HB, Jiang HH, Deng JC, Zhang N. Bone marrow niche adaptation, leukemic stem cell persistence, and therapeutic resistance in FLT3-mutated leukemia. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.119893
PDF	119893-in-press.pdf

Received	2026-02-10 01:58
Peer-Review Started	2026-02-10 01:59
First Decision by Editorial Office Director	2026-02-27 08:57
Return for Revision	2026-02-27 08:57
Revised	2026-03-09 08:51
Publication Fee Transferred
Second Decision by Editor	2026-05-29 02:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 06:55
Articles in Press	2026-06-09 06:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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