Publication Name	World Journal of Stem Cells
Manuscript ID	119895
DOI	10.4252/wjsc.119895
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Platelet-derived mitochondria transfer accelerates fracture healing by promoting osteogenic differentiation and metabolic reprogramming of adipose-derived stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Zhu Pan, Rui Zhang, Gai-Mei Du, Ji-Hai Yi, Jin Bao and Cai-Dong Liu
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Jiangsu Blood Transfusion Association Research Fund JSYK2024005
Corresponding Author	Cai-Dong Liu, Department of Blood Transfusion, Nanjing First Hospital, No. 68 Changle Road, Qinhuai District, Nanjing 210006, Jiangsu Province, China. liucd2281@163.com
Key Words	Adipose-derived stem cells; Platelet-derived mitochondria; Osteogenic differentiation; Glycolysis; Histone lactylation; Fracture healing; Metabolic reprogramming; Epigenetic regulation
Core Tip	Platelets promote glycolysis and osteogenic differentiation of adipose-derived stem cells (ASCs) by transferring mitochondria. Mechanically, mitochondria facilitate H3K18 lactylation, thereby inducing transcription of AXIN2, BMPR1B, COL1A1, and OSTN. Moreover, platelet-derived mitochondria enhance the effect of ASCs on fracture healing through glycolysis. Collectively, platelet-derived mitochondria transfer promotes the lactylation of H3K18 through lactate produced by glycolysis, promotes the transcription of osteogenesis-related genes, thereby promoting the osteogenic differentiation of ASCs and then accelerating fracture healing.
Citation	Pan Z, Zhang R, Du GM, Yi JH, Bao J, Liu CD. Platelet-derived mitochondria transfer accelerates fracture healing by promoting osteogenic differentiation and metabolic reprogramming of adipose-derived stem cells. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.119895
PDF	119895-in-press.pdf

Received	2026-02-10 02:51
Peer-Review Started	2026-02-10 02:53
First Decision by Editorial Office Director	2026-02-28 06:41
Return for Revision	2026-02-28 06:41
Revised	2026-04-11 06:46
Publication Fee Transferred	2026-04-22 02:38
Second Decision by Editor	2026-05-29 09:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 08:56
Articles in Press	2026-06-04 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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