Publication Name	World Journal of Psychiatry
Manuscript ID	119917
DOI	10.5498/wjp.119917
Country	China

Category	Psychology
Manuscript Type	Observational Study
Article Title	Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Chen Wu, Wei-Hua Sun, Qing-Qing Yang, Li Xue and Wen-Di Zhao
Funding Agency and Grant Number
Corresponding Author	Wen-Di Zhao, MD, Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Longzihu District, Bengbu 233030, Anhui Province, China. wendy1071@163.com
Key Words	Type 2 diabetes mellitus; Anxiety; Depression; Insulin resistance
Core Tip	This study highlights the substantial clinical burden of psychological symptoms in patients with type 2 diabetes mellitus, emphasizing that comorbid anxiety and depression are significantly associated with aggravated metabolic dysfunction. Those with concurrent anxiety and depression had worse glycemic control and greater lipid disturbances than individuals with either or no psychological symptoms. Notably, this comorbidity could independently predict severe insulin resistance, a condition featuring Homeostasis Model Assessment of insulin resistance elevation and Homeostasis Model Assessment of insulin sensitivity reduction. These findings suggest an amplified adverse effect of anxiety-depression comorbidity on insulin sensitivity, underscoring the urgency and necessity of metabolic-mental health integrated screening strategies to improve overall outcomes for type 2 diabetes mellitus patients.
Citation	Wu CC, Sun WH, Yang QQ, Xue L, Zhao WD. Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.119917
PDF	119917-in-press.pdf

Received	2026-04-14 09:55
Peer-Review Started	2026-04-14 09:56
First Decision by Editorial Office Director	2026-04-30 06:34
Return for Revision	2026-04-30 06:34
Revised	2026-05-14 16:05
Publication Fee Transferred
Second Decision by Editor	2026-06-10 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-10 08:04
Articles in Press	2026-06-10 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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