Publication Name	World Journal of Gastroenterology
Manuscript ID	119920
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	γδ T cells exacerbate intestinal fibrosis in mice with experimental colitis via activation of the CD73-adenosine receptor-cyclic AMP signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Wei Dong, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Dong-Chun Liang, De-Ming Sun and Cheng Lan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81860102, 82060102 Hainan Provincial Natural Science Foundation High-Level Talent Project 821RC1116, 822RC818
Corresponding Author	Cheng Lan, Chief Physician, MD, Professor, Department of Gastroenterology, Hainan General Hospital, Affiliated Hainan Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. lancheng71@163.com
Key Words	Intestinal fibrosis; γδ T cells; CD73; Adenosine receptor; Cyclic AMP
Core Tip	This study elucidated a critical pathogenic role for γδ T cells in driving intestinal fibrosis. Mechanistically, these cells promote fibrosis most likely by upregulating the CD73-adenosine receptor-cyclic AMP signaling pathway. Depletion of γδ T cells or pharmacological inhibition of CD73 attenuated fibrogenesis, as evidenced by reduced collagen deposition and profibrotic cytokine expression. Conversely, adoptive transfer of γδ T cells exacerbated disease severity. These findings nominate the γδ T cell-CD73-adenosine receptor-cyclic AMP pathway as a novel and promising therapeutic target for intestinal fibrosis.
Citation	Dong LW, Ma ZC, Fu J, Huang BL, Liu FJ, Liang DC, Sun DM, Lan C. γδ T cells exacerbate intestinal fibrosis in mice with experimental colitis via activation of the CD73-adenosine receptor-cyclic AMP signaling pathway. World J Gastroenterol 2026; In press

Received	2026-02-10 10:01
Peer-Review Started	2026-02-10 10:01
First Decision by Editorial Office Director	2026-03-04 09:01
Return for Revision	2026-03-04 09:01
Revised	2026-03-17 15:57
Publication Fee Transferred	2026-03-23 14:38
Second Decision by Editor	2026-04-20 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-20 06:21
Articles in Press	2026-04-20 06:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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