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Articles in Press
5/25/2026 9:02:28 AM | Browse: 5 | Download: 0
| Category |
Orthopedics |
| Manuscript Type |
Opinion Review |
| Article Title |
Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yang Yang, Guo-Dong Zhang, Ling Yi, Xu Yang, Zeng-Gao Han, Chen-Yu Song, Jing-Shun Lu and Kai-Yang Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Kai-Yang Wang, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com |
| Key Words |
Osteoradionecrosis; Small extracellular vesicles derived from human amniotic mesenchymal stem cells; Osteo-angiogenic coupling; Mitochondrial transfer; Epigenetic reprogramming |
| Core Tip |
Human amniotic mesenchymal stem cell-derived small extracellular vesicles represent a novel cell-free therapy for osteoradionecrosis. They reverse osteoradionecrosis progression through multi-target mechanisms - mitochondrial transfer, epigenetic reprogramming, pro-regenerative signaling activation, and immune microenvironment remodeling - offering a promising translational strategy for refractory radiotherapy-induced bone damage. |
| Citation |
Yang Y, Zhang GD, Yi L, Yang X, Han ZG, Song CY, Lu JS, Wang KY. Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration. World J Stem Cells 2026; In press |
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Received |
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2026-02-11 01:04 |
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Peer-Review Started |
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2026-02-11 01:04 |
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First Decision by Editorial Office Director |
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2026-02-28 06:41 |
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Return for Revision |
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2026-02-28 06:41 |
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Revised |
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2026-04-17 14:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-25 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-25 09:02 |
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Articles in Press |
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2026-05-25 09:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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