Publication Name	World Journal of Gastroenterology
Manuscript ID	119965
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Wei Liu, Yi-Ke Chen, Jin-Yang Yan, Hua Shen, Fang-Ming Mai, Zheng-Hui Kong, Hui-Long Chen, Li-Ping Li, Wei-Ping Liu, Yong Gao and Lun Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Fostering Talents in Basic Science of the National Natural Science Foundation of China 82304982
Corresponding Author	Lun Zhang, Chief Physician, Full Professor, MD, Department of Gastroenterology, Guangdong Provincial Second Hospital of Traditional Chinese Medicine/Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine, No. 60 Hengfu Road, Guangzhou 510095, Guangdong Province, China. 1214632861@qq.com
Key Words	P-element-induced wimpy testis-interacting RNA; P-element-induced wimpy testis complex; Gastric cancer; Function; Biomarker
Core Tip	Gastric cancer is a highly lethal digestive tract malignancy with unclear pathogenesis. Non-coding RNAs are closely related to its occurrence and development, among which P-element-induced wimpy testis (PIWI)-interacting RNAs have great research potential. PIWI-interacting RNAs (PiRNAs) regulate gene expression by binding to PIWI proteins and are abnormally expressed in gastric cancer tissues. This review focuses on PiRNAs and PIWI proteins, clarifies their molecular mechanisms in gastric cancer, and discusses their value as novel biomarkers for early diagnosis and targeted therapy.
Citation	Liu YW, Chen YK, Yan JY, Shen H, Mai FM, Kong ZH, Chen HL, Li LP, Liu WP, Gao Y, Zhang L. P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis. World J Gastroenterol 2026; In press

Received	2026-02-11 02:56
Peer-Review Started	2026-02-11 02:56
First Decision by Editorial Office Director	2026-02-27 10:18
Return for Revision	2026-02-27 10:18
Revised	2026-03-10 15:31
Publication Fee Transferred	2026-03-12 04:08
Second Decision by Editor	2026-04-21 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-21 09:09
Articles in Press	2026-04-21 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com