Publication Name	World Journal of Gastroenterology
Manuscript ID	119968
Country	Italy

Category	Surgery
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Management of incomplete resection of small rectal neuroendocrine tumours: An open question
Manuscript Source	Invited Manuscript
All Author List	Massimiliano Fabozzi, Maurizio Zizzo, Andrea Morini and Lorenzo Dell'Atti
Funding Agency and Grant Number
Corresponding Author	Lorenzo Dell'Atti, MD, Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Via Giovanni Amendola, 2, Reggio Emilia 42122, Emilia-Romagna, Italy. lorenzo.dellatti@ausl.re.it
Key Words	Rectum; Neuroendocrine tumours; Salvage therapy; Observation; Residual neoplasms
Core Tip	This sensitivity meta-analysis of studies with ≥ 36 months follow-up confirms that salvage therapy does not significantly reduce recurrence rates compared with observation after incomplete resection of small rectal neuroendocrine tumours (odds ratio = 0.89, 95%CI: 0.37-2.18). Despite a 25% residual tumour rate at salvage, long-term outcomes do not favour routine re-intervention. These findings challenge current clinical practice and support individualised management based on risk stratification rather than automatic salvage. However, given the low event rates and limited follow-up, current evidence supports shared decision-making with patients.
Citation	Fabozzi M, Zizzo M, Morini A, Dell'Atti L. Letter to the Editor: Management of incomplete resection of small rectal neuroendocrine tumours: An open question. World J Gastroenterol 2026; In press

Received	2026-02-13 01:42
Peer-Review Started	2026-02-13 01:48
First Decision by Editorial Office Director	2026-03-06 09:28
Return for Revision	2026-03-06 09:28
Revised	2026-03-26 09:40
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 09:41
Articles in Press	2026-05-07 09:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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