Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	119970
Country	United Arab Emirates

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Evidence Review
Article Title	Fontan-related protein-losing enteropathy: A comprehensive review of pathophysiology and current therapies
Manuscript Source	Invited Manuscript
All Author List	Eman Al Atrash, Doaa Zourob, Huda Alghfeli and Antoine AbdelMassih
Funding Agency and Grant Number
Corresponding Author	Eman Al Atrash, MD, Division of Pediatric Gastroenterology, Department of Pediatrics, Mediclinic Airport Hospital, Airport Road, Abu Dhabi 971, United Arab Emirates. emanalatrash8@gmail.com
Key Words	Protein-losing enteropathy; Hypoalbuminemia; Intestinal lymphangiectasia; Fontan circulation; Lymphatic disorders
Core Tip	Fontan-associated protein-losing enteropathy is a rare but life-threatening complication of Fontan circulation, driven by abnormal hemodynamics, lymphatic dysfunction, and intestinal barrier injury. This review synthesizes current understanding of protein-losing enteropathy pathophysiology and highlights contemporary management strategies, including nutritional optimization, targeted pharmacologic therapies, and emerging lymphatic interventions. Particular emphasis is placed on individualized, mechanism-based treatment and the evolving role of advanced imaging and interventional techniques. Improved recognition and multidisciplinary care have enhanced outcomes; however, refractory disease remains challenging, underscoring the need for novel therapeutic approaches.
Citation	Al Atrash E, Zourob D, Alghfeli H, AbdelMassih A. Fontan-related protein-losing enteropathy: A comprehensive review of pathophysiology and current therapies. World J Clin Pediatr 2026; In press

Received	2026-02-12 01:22
Peer-Review Started	2026-02-12 01:27
First Decision by Editorial Office Director	2026-02-25 08:01
Return for Revision	2026-02-25 08:01
Revised	2026-02-26 21:13
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:24
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 09:59
Articles in Press	2026-05-07 09:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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