Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	119973
Country	Serbia

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Rethinking Helicobacter pylori-associated gastroduodenal disease through a systemic immune lens
Manuscript Source	Invited Manuscript
All Author List	Nebojsa Manojlovic and Stevan Manojlovic
Funding Agency and Grant Number
Corresponding Author	Nebojsa Manojlovic, Full Professor, MD, PhD, Clinic for Gastroenterology and Hepatology, Military Medical Academy, Medical Faculty of MMA, Crnotravska 17, Belgrade 11000, Serbia. nebojsa.manojlovic1@gmail.com
Key Words	Helicobacter pylori; Systemic immunity; Immune imprinting; Gastritis; Duodenal ulcer; Cytokine signatures
Core Tip	Emerging evidence suggests that Helicobacter pylori-associated gastroduodenal diseases are shaped not only by local mucosal inflammation but also by stable, phenotype-specific systemic immune states. Recent findings indicate that bacterial eradication induces distinct systemic immune recalibration in gastritis and duodenal ulcer, particularly involving regulatory pathways such as interleukin-10 signaling. Recognizing this systemic immune dimension may refine the interpretation of immunological data and inform future research beyond a purely gastric framework.
Citation	Manojlovic N, Manojlovic S. Letter to the Editor: Rethinking Helicobacter pylori-associated gastroduodenal disease through a systemic immune lens. World J Gastrointest Endosc 2026; In press

Received	2026-02-24 08:26
Peer-Review Started	2026-02-24 08:27
First Decision by Editorial Office Director	2026-03-06 09:21
Return for Revision	2026-03-06 09:21
Revised	2026-03-10 23:35
Publication Fee Transferred
Second Decision by Editor	2026-04-07 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-07 10:01
Articles in Press	2026-04-07 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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