Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119999
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Comparative study of one-step and four-step injection combined with external stripping and internal ligation for mixed hemorrhoids
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Han Li, Xian-Shu Wu, Lun Zhao, Xue-Feng Liu, Wei-Ru Lan, Wan-Ni Sun, Na Zhao and Yue-Dong Liu
Funding Agency and Grant Number
Corresponding Author	Yue-Dong Liu, Chief Physician, The Third Anorectal Department, Liaoning University of Traditional Chinese Medicine, 35 Shiwei Road, Heping District, Shenyang City, Liaoning Province, Shenyang 110005, Liaoning Province, China. 19550305937@163.com
Key Words	Mixed hemorrhoids; External stripping and internal ligation; Sclerotherapy; Four-step injection method; One-step injection method
Core Tip	This retrospective study compared one-step vs four-step Xiaozhiling injection combined with external stripping and internal ligation for mixed hemorrhoids. The four-step method significantly reduced postoperative pain on days 1 and 5 and shortened hospital stays compared to the one-step method, with comparable surgical time and no recurrence at 6 months. These findings suggest the four-step injection technique offers superior postoperative recovery and represents a clinically valuable optimization for mixed hemorrhoid surgery.
Citation	Li SH, Wu XS, Zhao L, Liu XF, Lan WR, Sun WN, Zhao N, Liu YD. Comparative study of one-step and four-step injection combined with external stripping and internal ligation for mixed hemorrhoids. World J Gastrointest Surg 2026; In press

Received	2026-02-12 03:05
Peer-Review Started	2026-02-12 03:07
First Decision by Editorial Office Director	2026-03-12 07:44
Return for Revision	2026-03-12 07:44
Revised	2026-03-17 09:10
Publication Fee Transferred
Second Decision by Editor	2026-03-30 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-30 07:03
Articles in Press	2026-03-30 07:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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