Publication Name	World Journal of Gastroenterology
Manuscript ID	120001
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Helicobacter pylori retreatment: When clinical guidelines meet patient reality
Manuscript Source	Invited Manuscript
All Author List	Ze-Yan Ren, Li-Ping Liang, Ying Deng, Mu-Di Yang, Zhi-Qing Wang and Le Liu
Funding Agency and Grant Number	Funding Agency Grant Number the Guangdong Basic and Applied Basic Research Foundation No. 2023A1515111183 and No. 2026A1515010582
Corresponding Author	Le Liu, MD, PhD, Principal Investigator, Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, No. 253, Middle Industrial Avenue, Guangzhou 510280, Guangdong Province, China. 1402744723@smu.edu.cn
Key Words	Helicobacter pylori; Eradication failure; Rescue therapy; Retreatment; Adherence; Shared decision-making
Core Tip	The antimicrobial resistance is not the only cause of the gap in treatment after eradication failure. The variables, which are likely to be contributing to this situation, include treatment load, past ill effects, non-compliance and break-off, communication failure or miscommunication, or break-off of follow-up. Although better rescue regimens will be required, they will not fill this gap on their own. Failure should be followed by structured reassessment, patient specific counselling, and tangible follow up.
Citation	Ren ZY, Liang LP, Deng Y, Yang MD, Wang ZQ, Liu L. Helicobacter pylori retreatment: When clinical guidelines meet patient reality. World J Gastroenterol 2026; In press

Received	2026-02-12 01:22
Peer-Review Started	2026-02-12 01:27
First Decision by Editorial Office Director	2026-03-17 10:30
Return for Revision	2026-03-17 10:30
Revised	2026-04-14 10:33
Publication Fee Transferred
Second Decision by Editor	2026-06-02 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-02 07:13
Articles in Press	2026-06-02 07:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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